Roland Deschain, the Gunslinger, has a pair of revolvers made from the metal of a shattered Excalibur.
Karl Zermann (Ozo) from Tannhauser has a demon-possessed Borchardt c-93 that can shoot around corners.
Hellboy has the Samaritan, an enormous 4-shot revolver made from melted-down church bells.
Alucard from Hellsing has his Jackal, a massive 13
mm automatic with anti-undead powers.
I think a lot of animes have special guns for their characters that might make good relics and magic items, but I can't really think of any other good ones off the top of my head..
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