I enjoy both games. A lot.
LNoE is good for variety in characters and more of a 'teamwork' theme. I haven't had a chance to play with the expansion yet, but I have it and it looks just as good as the base game.
Zombies!!! is great for more randomness as the board will be different each time you play and there are multiple ways to win. And with expaensions there are more Helipad locations so everyone isn't always going the exact same location.
If I had to pick one I would reluctantly choose LNoE. Simply because it doesn't suffer from the bloat of numerous expansions that need (if you are like me) to be bought for completness sake.
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