For one, the condition track feels nice when I'm shooting at someone, but felt very out of place when we used it with the fantasy game I played. The players seemed to be constantly beaten down.
The AC system wasn't my preference for a fantasy game (we had to work around quite hard to get heavier armors to feel right)
The force worked "ok" for magic, but it was quite over-powered if you just took skill focus UTF. This, with the limited amount of force powers worked ok with the very low magic world I was using, but wouldn't have been as nice if a wizard had been in the party.
The movement system is made for run'n'gun, rather than sword fighting, so ranged characters are far more effective seeing how they can freely move 1/2 speed away from an enemy and continue to attack them. This limited the usefulness of any multi-attack melee strikes.
As such, I find the game works wonderfully when using it to mimic a Firefly-esque game, or even a d20 modern game with little or no magic.
Combat-wise, though, I feel
4e was an improvement for more melee-focused fantasy games. YMMV
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