They affect everyone plenty.
I liked my Dungeon and Dragon magazines. They were awesome. Then they went away. Now they're back as part of a horrid electronic-only boondoggle.
I liked using adventures and supplements from Green Ronin, Atlas Games, etc. I liked
OGL variants like Mutants & Masterminds, Conan, et al.
WotC tried to crush them using anticompetitive language in the first
GSL, but has backed down to settle for "no more where that came from!" (Of course the
OGL stuff can still flourish outside their grasp, but there can't be that innovation on the current D&D branch.)
I liked buying some things in PDF for easy searchability (Spell Compendium!). Now, I can't.
So yes, if your gaming life was entirely homebrew or totally limited to "whatever one product
WotC wants to sell me this month for the current version of D&D only" - all these moves won't affect your gaming. For me, however, it does.