Interested. Especially if it's M&M which is one of my favorite systems.
And yeah, 'slayers' are pretty generic in the aftermath of season 7. And Sunnydale's hellmouth was destroyed (along with Sunnydale), so probably not much reason to set it there.
But the setting supports a whole lot of weird concepts. Creatures from other dimensions, lycanthropes, reformed demons, psychics, magicians, robots...and the source material suits most RPG's in that the shows all revolve around "gatherings of freaks," which is what most gaming groups wind up making anyway.
(psst...coughstarwarsgamecough)