| So I handle this in two ways:
First, the p42 guidelines are your friend in terms of damage. If they are talking about doing something that doesn't cause damage (like blinding with flour) then I'd be much more inclined to impose a -2 or -4 penalty to attacks than to allow them to actually be Blinded.
BUT I also have "Power Stunts", which is where they spend an Action Point + Healing Surge and get to do something extra cool. Since this is a limited resource then I don't mind it exceeding the normal limits of the p42 guidelines.
So far this has worked extremely well in my current campaign. | 
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