For me personally-without getting in an EW- Pathfinder will never scratch the itch because I'm just not a fan of 3.x in the grand scheme of things (great intentions, poor execution- *for my tastes*). PF seems to cater even moreso to the 3.x style gamer- and thats great, good for them, glad they have a game to scratch the itch!
I've got
4E to scratch my new millenium D&D itch and I've got the LBBs, S&W, S&S, BFRPG, Moldvay/Cook/Marsh and 1E/2E when it itches in that "old school" spot
EDIT- I shouild point out that only the above mentione d D&D games "scratch my D&D itch". BUt I love all kinds of systems, and sometimes I need to scratch the CoC itch or the RQ2E itch or WEG StarWars itch or Herowars/Heroquest (Glorantha) itch.
No one game covers all itches.