Personally, I don't find bookmarks particularly useful. My experience with them has indicated that they make a good "checklist in a review" kind of thing, but they don't seem to add anything to the usability or experience that (Ctrl)+F doesn't already give you.
A document short enough that you can navigate the bookmarks without scrolling is short enough that hitting the right or left arrow keys will jump you anywhere in the document you want to be. A document long enough that you need the bookmarks makes the bookmark list unwieldy. And is a bit long to be reading on a computer with (Ctrl)+F anyway.
There's a happy medium, somewhere, in which you have only the most important areas bookmarked in a long file, but even this doesn't save you gobs of time if you are looking for something specific within the document. MUCH more useful, in my opinion, is a well-designed Table of Contents or Index, either one. Hyperlinks is a layer of icing, but is not required for usability.
Of course, if you want good reviews of a PDF document, I'm given to understand that you need to include bookmarks of some sort

.