I like you're idea of highlighting the most useful information. You might try using some different shapes though. There are a lot of bold circles so they tend to blur together. Shapes to make saves stand out from HP and AC, for instance, might work better. Also that whole section on the front page takes up too much space. You've got skills scrunched in at the bottom with 11 lines of information in less vertical space than the 6 lines needed for ability scores.
If you want to keep that clean open look on the front page, maybe put something less space intensive on the front instead of skills. I'm a big fan of sheets with a space for magic items by body slot- which would fit pretty well in the space you have skills now. Using 3 columns you could list all the body slots for items, main and off-hand items plus a few slots for temp items like potions and scrolls. All of which is very useful to have on the front page of a sheet- less flipping around look for vital info.
As for the spells section- honestly I would drop it completely and make up a optional 3rd sheet for spell info. If you're playing a caster the space allotted for spells on the back of a 2-page design will never be big enough to actually use anyway and if you're not playing a caster it just becomes wasted space- so I say drop it completely. A 3rd sheet just for spell info allows you to format it in a way that makes it useful. Personally I think
Neceros' spell sheet works best- it's what I copied from to make my own sheets.
Other than that I would just look at how much writing space your various boxes for info allow. As in- do you have enough space to actually write your weapon info and such? A lot of sheets look great but wind up being too cramped in some areas or too open in others. That's something you can only figure out by printing a test page and actually writing up a sample character. That's what I did to tweak the spaces for my own sheet design.