Slit518
Adventurer
I don't play video games, so I couldn't tell. My gaming group is made of French-speakers, so my setting, titled "Les Contrées sauvages", was written in that language. For the purpose of this thread, I translated the name to the closest English equivalent I could think of.
There are quite a few myths from which I stole, sometimes consciously, sometimes not (I also plead guilty to stealing the riff between the dwarves from Dragonlance).
When I wrote my setting, I decided to have the distant past be mysterious, in the spirit of old school D&D and weird tales of the 1930-1940s. If you re-read my post, you'll notice I never said the Progenitors created the 144 humans. Perhaps they did, or perhaps they had found them elsewhere, perhaps the Progenitors were human themselves. I thought of a few theories, but decided to leave it open.
One devious theory I had was the the Progenitors were mind flayers (aliens one, with superior technology) and decided to have the Savage Lands as some sort of game reserve. They would come back in force, when Humanity was more numerous, a bit like some people stock lakes with fishes, let them multiply and fish them afterwards. The most obvious theory is that the Progenitors saw humans as their ultimate creation, but then, as the Black Book explain how to create new species from existing ones, not create ones whole cloth, so from what specie did humans evolve?
For the sake of mystery, I also decided to left the cause of the Wrath of the Gods as an unsolved mystery. Most inhabitants believe it's the gods (it isn't), but there are other theories. What if the Progenitors always kept a watch on Humanity and decided it was a time to put an end to their grand experiment?
Would "Les Contrées sauvages" actually translate to, "The Wild Countries," or "The Wild Lands?"
A Progenitor is like a relation of something, correct? Like something that came before? Kind of like a Wolf might of been a Progenitor of a Dog?
It reminds me of the Anunnaki creating humans because it is said to of worked this way - the Anunnaki were masters of gene manipulation, and DNA, or so it is said. It is also said the Anunnaki mixed/fused their DNA with either the apes of this planet to create modern humans, or other human like people, such as Neanderthals or Cro Magnum as an example.
It might not be correct to your lore, but just from your story, I go an imagination that the Progenitors came to the planet, mixed their DNA with whatever other creature/race, and Humans are what became.
P.S.
The Anunnaki apparently made Humans in their image, aka using their DNA to make the perfect "slave." This story on the 5,000+ year old tablets gets a lot deeper, and can be found out more through The Epic of Gilgamesh. If you haven't read it, take a look at it, it is some interesting stuff. Though a lot of conspiracy theory surrounds it.