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Message: <blockquote data-quote="babinro" data-source="post: 5176572" data-attributes="member: 67482">I should note that the monsters I've run from books are exclusive to the  Monster Manual 1&2.  Without any actual numbers to back it up, the feeling I've had having DM'd 29 levels so far is that Fortitude is a big deal early on as Poison is very prevalent in heroic tier.  As you get into Paragon, you see a lot more Reflex attacks as enemies tend to get more area/close attacks.In epic you'll find a lot of Will/Reflex attacks because of bursts and Charm effects like domination.I'd have to say from my experience, they cover all defenses pretty well throughout the game.  But if you wanted to shore up only one defense, it would probably be Reflex giving you the most bang for your buck during most the campaign.  Perhaps retraining to Will during mid-epic on as it covers a lot of mean conditions.Though I am of the mind that you can't really compensate for a low NAD with feats to begin with as you'll get hit frequently regardless from my experience.  As such, I'd personally only spend feats to further improve your strongest non-AC defense in the hopes that it will protect you on over 50% of attacks made against it.</blockquote>