I watch Adult Swim just about every night. Not because I'm really into it, but because there's just not anything else on that entertains me.
I don't care for most of their "homegrown" cartoons (Mouse, Squid, ATHF, Hair). ATHF disturbs me, and I just don't have any interest at all in the other ones. Except Harvey Birdman. I drop everything for Harvey.
Chaldfont said:
Boondocks: This is a very well-made show. Great voice acting, great soundtrack, great writing. They even got Samuel L. Jackson to do a voice--of a white guy!
Wait. The militant poseur with the itchy trigger finger and the bandana was Samuel L. Jackson? Holy... I
thought he sounded familiar.
I think that The Boondocks is the highest-quality animated series to come out this side of the Pacific. The animation is worlds better than everything else, and while it does have a great deal of "offensive" material, it's always used as satire, not just thrown out there randomly to offend people like Family Guy does. The show has a point, and that's what matters. I do disagree strongly with a lot of the opinions put forth, but I don't begrudge anyone their opinions. Also, although Huey is obviously the mouthpiece for the creator's views, he's portrayed with faults of his own, which I appreciate.
The only thing about The Boondocks I
really dislike is the 30-second "bumps" before each episode where the Adult Swim staff sucks up to Aaron McGruder, the show's creator, like a bunch of big sycophants. Bleh.
Lemme see... as for the rest of their lineup...
Futurama: The Boondocks may be better-drawn and better-written, but Futurama is just so much more good-natured. Out of the American-made shows on AS, I like Futurama best. It's always a hoot.
Going off on a brief tangent, I had no idea until recently that Green Lantern from Justice League, Jack from Samurai Jack, Static from Static Shock, Black Vulcan from Harvey Birdman,
and Hermes from Futurama are
all voiced by the same guy, Phil LaMarr. Damn, that guy is versatile and gets around.
Family Guy: Irredeemably bad. Stewie and Brian are funny, but the rest of the cast just pisses me off with their stupidity.

Plus the only point of the show seems to be tossing out as much offensive crap they can to piss off as many people as possible. It's just crap.
American Dad: I've seen very little of this show, but from what I can tell it's just a politically-pointed retread of Family Guy with slightly different characters and a different premise.
Then there's the anime, which is the main reason I watch AS. There's just a much greater emphasis on storytelling and character development, and the animation is better drawn and flows way more smoothly too. It's also largely free of the snarky cynicism that bogs down much American animation.
Fullmetal Alchemist: My favorite show on the network. Funny, poignant, occasionally thought-provoking, and always entertaining. The show is gold. Transmuted from lead, even.
InuYasha: I dig this show, but only when the plot is moving forward. Most of the time, it's bogged down with episodic "filler" that does nothing to move the story along. I'm intrigued by the ongoing story with Naraku, his minions, Kikyo, and all that, but there are too many detours from the plot. I also get a little tired of the "my kung fu is stronger than yours" crap where InuYasha has to overcome some random obstacle so he can keep going against Naraku; it's really tiring. A mediocre show that could have been better.
Ghost in the Shell: Haven't seen much of this show, and since I don't really like cyberpunk I'm in no hurry.
Neon Genesis Evangelion: I'm trying to figure out why everyone loves this series so much, and so far I'm coming up blank. The robot action? Robot shows are a yen a dozen. The psychodrama? All I see is a bunch of head-cases with sticks up their butts. Misato's jiggling chest? I like to think my fellow enthusiasts have better taste than that.

I've been watching this show for about a month now, and I just don't get why so many people claim it's the end-all be-all of anime.
Samurai Champloo: Gawd, I LOVE Samurai Champloo. The blend of action, adventure, humor, drama, and hip-hop in a guided tour of 17th-century Japan could have been a total mess, but here it's nothing short of inspired. Great characters, great writing,
amazing animation... ye gods, I love it.