Any multi-target attacks will allow you to target multiple enemies in a round. If you don't mind trying a hybrid build, a fighter with Hellish Rebuke or Dire Radiance can be quite nasty, as the target either takes extra damage for moving towards/damaging the fighter, or the fighter gets to use his marking ability. I've tried a similar build, and if you want to save on weapon/implement swapping, you can go with the Tempest Fighter and wield a Pact Dagger (which I think can be any light blade) or take Arcane Implement Proficiency.
If you are doing multiclassing rather than a hybrid build, I'd pick up Hellish Rebuke or Dire Radiance as your dilettante and get Versatile Master at paragon, to use that power at-will. If you have a DDI subscription, there was a great article recently that boosted Half-Elves considerably (there are a few threads about it).
Generally, you'll want multi-target attacks to curse ranged foes. If you're going for a more fey-oriented character, you can instead opt for teleporting powers to move around the field as you will (and Eyebite is pretty good to mark with, since they attack you with a -5, or attack anyone else with a -2 and whatever else your mark might grant).