That's the rub, though, a "nod" and "creativity" can be highly subjective. And how far back does one establish this criteria?Some nod to creativity and not just profit would be nice.
So far 5e has done lots of creative stuff that's been mentioned above. Some people might love the idea of a body horror biotech "necromaner" is the bee's knees but not be impressed with turning hell into a Mad Max homage.
And despite its other flaws, some fans may not like Spelljammer plot of stopping a massive sun-powered doomsday device because they don't like the setting in the first place, or if they are big sci-fi fans, feel like they have seen this before despite it being in a fantasy D&D setting.