I haven't seen any specific confirmations, yet, but it sure seems like Forgotten Realms is gearing to be Next's default setting. I don't have anything in particular against the Realms, it just has never caught my interest. I would not look forward to FR being the default, and would prefer other options.

I really liked 4Es PoL: in my opinion it harkens back to D&D's history and inspires new ideas and adventures.

But what does everyone else think?

Something entirely new
4E's PoL, Astral Sea/Elemental Chaos
3E's Greyhawk/Plansecape mash-up
Forgotten Realms
Dark Sun
Some combination of the above?
No default setting at all
It doesn't really matter