If intelligent life persists, then it should eventually be able to make Van Neumann probes and have them be nearly everywhere in the galaxy. We might be only a century or so away from doing this ourselves.
Yeah, but then it's millions of years to spread. I think the estimate is 10 million years at 0.5c? I may not be remembering correctly, though; it's been a while since I've read about that.
I think you get back to the Fermi Paradox pretty quickly.
Yeah, that's basically what this thread is about. We're all positing the standard solutions to the Fermi Paradox.