Setting player expectations is important. I play mostly in sanctioned games, which means the GMs can't really modify anything anyways. I'm still able to lay out some character lore, but I'm playing those characters in the current situation. My rogue/bard burlesque saloon performer who worships a...
I generally use the Venture Brothers as my model, which is a good 80% comedy but with enough drama to make things hurt. In general it's good to set tone expectations, and the DM can enforce a lot of it with the nature of consequences.
There is quite a spectrum, which is much of the fun of the game. The goofy moments are often what allow the serious moments to hit - you don't cry harder than for the characters who make you laugh.
Generally the DM only needs to actively weave in PC backgrounds a few times per PC over the course of the campaign unless they want to make the campaign heavily about the PCs. If you're just running a module or something you can sprinkle in "Hoy you like a bit like the duke but hawww that's a...
The dates for the wild west era and larger-scale Japanese immigration actually check out, or do you mean strictly "Spaghetti Western"? Also the irony of western films based in samurai movies
Humanoids Handbook is 2E, as are Planescape and Dark Sun. D&D's greatest competition was a system full of vampire and werewolf PCs. This has all been common for longer than most 5E players have been alive.
I can see there being some concerns if the setting greatly limits travel such that it's very difficult for populations to circulate. A setting where tourism and international trade would be fictions.
I'm saying they're people. Their differences don't make them not people.
If a space bug from Alpha Centauri landed on Earth and wanted to play a game I'd help them sign up for Pathfinder Society and ask if they need to borrow dice or a mini.
If I was a dwarf living in Faerun, and a mind flayer...
They're all just people. It's only remarkable to us because all the other people in our world went extinct before we could hang out with them. The vast majority are exactly as normal as humans, with the occasional person who is a sentient moo or something.
If the real world had people with...
The more defenses the more spells/abilities you need. May as well bring back different AC values for bludgeon, slashing, and piercing while you're at it.
Howling about howling aside, Dark Sun Classic was a demonstration of how far from core a campaign can be while still working at a large scale. Modern games are full of optional rules and flavor suggestions that can add up to something like Dark Sun. It's evidence that you could also build a...
PS had a great 3P book come out (drama aside) around the time of the official set. I expect DS will have similar results. Folks who are passionate about a thing for decades have some advantages when writing to other folks of similar passions.