I did an apocalypse Chuthulu game. Everyone makes characters of themselves. In game, The end of the world starts while the PCs are playing an RPG. It's all a bit meta.
In any case, the person hosting the game lives near a big lake. I called his wife ahead time (she wasn't going to be playing) and asked her to randomly start asking weird questions like, "hey, do you see people out in the lake?" "Who'd be out this late at night?"
His answers to the questions were, "probably the neighbors fishing" etc...
She kept it up, occasionally interrupting our game and even pretended to call the neighbors to ask about the "People on the Lake".
She then retired to the office to get some work done. I then started describing stuff in-game that resembled the stuff she'd been saying (all the while creepy music in the background).
Then I said,
"You suddenly hear a horrible scream from the office! Bob, it's the sound of your wife screaming!"
The scene continued for a bit and I could see that Bob was looking uncomfortable as it involved us barging into the locked office to discover his wife going missing and my 'character' (me) getting bludgeoned to death by his possessed neighbor..
Out of Character, I said, "Bob, you look uncomfortable, do you want to check on your wife?"
He stands up and goes to open the door to the office but it was locked. He starts frantically banging on the door but his wife was wearing headphones while she was working and never opened the door. We were laughing so hard. The poor guy. His wife thought it was hilarious.