I've just started a Ptolus campaign. You can see how it's going by reading my
Praemal Tales.
I guess you'd need to be more specific about the kind of advice you're searching for. Is there something in particular that makes you seek advice? An issue on your mind, in particular?
My general advice would be to try to use the substance of Ptolus, to embrace its nature rather than try to reject it. What I mean by the nature/substance of Ptolus is twofold:
First, Ptolus is a setting that doesn't try to impose a playstyle but actually in my opinion succeeds in blending them almost to the perfection. Read the chapters on Running Urban adventures and campaigns in particular, and how to blend investigation, character interaction with dungeon crawling and action. Ptolus has a surface and an underground which have different characteristics with different kinds of appeal as far as playstyle is concerned. To get the most out of Ptolus, I think the best is to play with this in mind and alternate investigation/NPC interaction/surface scenarios with dungeon delving/action scenarios.
Second, Ptolus is D&D through and through. It's a point that is similar to my first idea, yet different enough to consider closer. To get the most of Ptolus, in my opinion, one needs to consider the core D&D experience and try to use the most of it. Ptolus works best in campaign running from 1st to 20th level, for instance. It works best by blending playstyles, again, and by alternating event-based and site-based adventures. By thinking about character builds, class abilities and using them in the game. So on, so forth.
Beyond this general advice, I'd need more specifics about your concerns. Hope this helps so far!
