If I can ask a question related to the one I asked in the "difference between optimized and non-optimized" thread:
What is the difference between a party of PCs with the "math fix" feats and a party of PCs without the "math fix" feats anyway?
At the most basic level, I suppose one could look at how likely is the party to overcome the challenges they face in the game. However, assuming that even a party without the "math fix" feats already has a good chance of overcoming an equal-level challenge (and admittedly, I don't have any mathematical support for this assumption) then replacing some of their feats with the "math fix" feats would only lead to a marginal increase in the chances of success.
If we look at the amount of resources used to overcome the challenge, the only resources that are not renewed after a short rest (or two, in the case of action points) are healing surges, daily powers, and consumables. And in the case of healing surges, a character with the "math fix" feats that ends up being hit only once during the fight and a character without the "math fix" feats that ends up being hit twice may end up spending the same number of healing surges to recover hit points during the short rest.
If we expand the time frame further, even the number of healing surges expended and daily powers used wouldn't make much of a difference if both the parties end up taking an extended rest at the same point in an adventure regardless of how many healing surges and daily powers they have at that time (e.g. there is a logical break in the action - the party has just cleared out a dungeon, for example - or at the end of the adventure).
RangerWickett did raise a good point about the speed of combat. So, if you want your fights to end more quickly, there may be an advantage in taking the "math fix" feats.
Otherwise, do the "math fix" feats simply allow you to look better when you're winning your fights?