I just want to quickly answer the OP before going off on a tangent:
I generally prefer to make my own domains, and I mostly like Darklords as backdrop.
Now as a tangent on the idea of souls vs no souls:
It makes me think of a book by Chuck Klosterman called 'But What If We're Wrong?' where there's a chapter talking about the idea that we might be living in a computer simulation, and how if it turned out that that was the case it would make no difference to how we live our lives. Interesting stuff.