Well, I always drink when I'm DM'ing, and it's never done me anything but good (loosens me up, lets me not sweat the small stuff etc).
But this one time while playing Champions, one of my players brought over some cookies that were liberally laced with a certain herb that I'm not sure Eric's Grandma would appreciate my naming. One cookie for each player, and one for his DM.
Now, I'm not much for this herb. I don't use it in my everyday life because I don't smoke (period) and have trouble holding the smoke in for the time necessary.
The cookie seemed like a decent way for me to enjoy this experience with my friends.
Apparrently it had a
lot of active ingredient in it (so much so that the regular users in our group commented on it's strength) and about 11pm I just, literally, could no longer think.
I couldn't rememeber what part of the game we were in, what my NPC were supposed to do, what the plot was etc.
at about 11:05 I just called it.Just "OK, we are done for the night"
One of my players said "Uh, can I finish rolling?" (he was in mid-action)
My response was "you can, but there's no way I can tell you what effect your actions will have."
I was stunned how empty my mind was while under the influence. Just "empty". Until that moment I was unaware that I have a near-constant inner dialogue. You miss it when it's gone
I just stick with my Scotch or Vodka/Fresca Nowadays