Hmmm...
Wii: Muramasa the Demon Blade, Little King's Story, possibly many more. I have a feeling we will see more good titles for this one soon. Certainly I will get several more Virtual Console titles.
XBOX 360: Probably a few things, now that I got one for Christmas. Nothing immediately comes to mind, though... Star Ocean 4, possibly.
PS3: White Knight Chronicles and Valkyria Chronicles. I know the latter is out, but I am waiting for the former before I bother to get the console.
DS: Suikoden Tierkries, Avalon Code, and Fire Emblem Shadow Dragon, and that is just for the next few months. Probably many more as more stuff starts coming out, like Dragon Quest 5 and 6.
Mac: Starcraft II. I hope my computer can run this, since this is the only PC/Mac game I will want for the next few years...