For less powerful creatures, I remember once that my first DM threw a horde of Orcs at us. Now, don't get me wrong, we thought we were going to step in, Fireball, and walk away... but that didn't quite work out as planned.
None of them had weapons. They merely swarmed over us, pinned us to the floor, and knocked us unconcious from repeated blows to the head.
With no spell components, no weapons, no armour, and no items, our company of 6th-8th level characters were effectively useless for quite some time in that campaign.