If you are not an inveterate d20 tinkerer, then Spycraft may not be for you. It's very cool, don't mistake me, but if you want setting and rules, and you want something that moves smoothly and quickly, Shadowrun 4e may be worthwhile. Reduction of everything down to successes, rather than successes and target numbers, doesn't sit well with a lot of the fans, but it does look like it makes things smoother. I've had the PDF since early this month (I got curious), and the rules mechanics seem to read smoother (though I haven't gotten to rigging and decking yet).
Spycraft, awesome book, but a few of the extras in combat strike me as a bit overworked. Phil Reed may love having two conditions for being laid flat, but in practice it strikes me as having a lot more conditions to worry about than the 15 or so I already know (sickened, nauseated, stunned, prone, dazed, etc. etc. etc. and now sprawled, plus a couple more? Ungh!) I love the dramatic conflicts though.