Cyberpunk is a clear example about how the sci-fi get old very bad. Today new generations miss a lot of current technology what doesn't appear in older works.
Cyberpunk isn't only about the bad use of the technology, but about the society and how we could go to a dystopian, but today people are changed their ideas about the true causes of this dystopia, and the great difference between Detroit in the Robocop movies and from the real life.
In the RPGs the "neopunk" is going to be replaced by the transhumanism, with the digital immortality and mind transfer, and that changes the gameplay very much. "Cyberpunk 2020" is going to be killed by Eclipse Phase, the game where the crunch is the wet dream of munchkins but this doesn't avoid an all-party-killed game.
* Were there rules about genetic engineering for "transgenic" humanoids in Cyberpunk 2020? Have you thought about the impact if we find the secret of eternal youth and the retirement by old wouldn't be necessary? To find a new job would be harder for just linceced, and the ascend in the company when the boss always will be there but if he want to create his own new businessmen.
* Shadowrun has got a better future because it adds fantasy, and this allows a "softer" style and more options for new adventures and plots.
* In the speculative fiction megacorporations can be antagonist factions, but if we abuse this cliché, then the settings become boring. We need different types of villains. And for God's love! I don't want that type of crazy characters like Dolph Lugren's one in the movie of Johnny Mnemonic. They are really annoying. When was the last time of a villain like Cuervo Jones in "Escape from L.A".
* Have you thought about stories set in arcologies (mega skyscrapers) as micro-states with their own laws and sovereignty (in the former region of a now failed state), created and controlled by megacorporations?