Having not played this system, but having read the source material for The Strange, my opinion matches most answers here - I love the setting, I like the idea of using stat pools as both health and effort resources, but find the combat, encounter and exploration rules really lacking. The fact that any monster of the same threat level has the same AC, damage, and HP seems way too flat. And given the wildly open description of the setting, I found the sample adventure clunky and lacking in sense or inspiration.
All that said, I like the setting so much that I'm seriously considering running it as a 5E game, and just reskinning D&D monsters to Strange critters, cyphers become single-use magic that the players collect on a regular basis, and making characters for different worlds feels like it would go faster if I just say, "D&D classes, these are the ones available, give me an expertise and we'll call it your sub-class". All my players are very familiar with 5E, so character building this way makes sense to me. I'd really like to use the stat pools, but haven't figured that out yet.
Anyone want to talk me out of this? Does this sound workable?