Neat
Im actually running a game set in the Fallout universe with a few differences
A) Ive set it in Florida. Im Australian but managed to get a map of miami and outlying areas so Ive been using that as my background info
B) Created and placed some vaults of my own (one of which provides the player characters)
C) Introduced the Cubans as one group of 'baddies'. Technically they are remnants of a strike force that invaded America just before the Nukes were launched. There are smatterings of Russians amongst them too.
D) Brotherhood is more akin to Fallout 1 and 2. Interested in Technology at all costs and not really good or evil. They just are. Their attempt to safeguard technology was they boobytrapped a town library the party was going through.