I was thinking 6th level. I want it to be cinematic, but for my first game, I don't want them to be *too* high a level.
The PCs won't really be the Losers, but the first several comics will be required reading and each of the players will be asked to make a character based on the skills and archetype of one of the main characters. The campaign might open just after issue #12, (depending on what that looks like), with the assumption that everything that has occured to the Loser characters has just occured to their characters.
I don't have Spycraft or Blood and Guts and can't really afford to pick them up right now, but I'll browse through them and read some reviews.