Shemeska
Adventurer
I really liked 4E's Points of Light setting, and I feel it made a great default setting that was at both times unintrusive and sparked the imagination.
It was many things, but unintrusive was one thing it was not. It forced massive changes to FR, dropped primordials, eladrin, and various other PoL core concepts into Dark Sun... it even shamelessly altered the history/nature/origins of a huge number of classic D&D creatures and concepts. It was anything but unintrusive.
If Nentire Vale / PoL is the default setting for 5e with a similar level of saturation and intrusion into other campaign settings, it's a deal breaker for me.