Yes, I have. One of the PCs had a long-lost older brother. In his background story, they were soldiers together, then his brother took a leg wound, their army lost the battle, and the PC deserted; he could either die with his brother, or flee (leaving his brother behind) and become an adventurer. The DM made the brother into vengeful undead, which attacked the party as an ally of an assassin from the BBEG.
Meanwhile, in real life: my older brother died last year. So the storyline with the PC's brother was emotionally intense for me.
During that night, in game time, my paladin PC prepared Ceremony, and the next morning, the PCs held a proper burial, and laid the undead to rest. I spoke, in character, with feelings from my own brother's funeral, and some of the same words. Rest in peace.