I just don't think a single boss monster is a challenge in this addition without a lot of reworking once you get past a certain level.
One of the things I wanted to do that is really simple is scale bonus STR damage with size. It's kinda silly that a Gargantuan beast with a 30 STR does little more bonus damage than a 20 STR human sized thing. Add in a x2, x3, x4 multiplier for size and big things become very scary again. We increase the carrying capacity by size, so this isn't really an illogical step. So yes, the Tarrasque gets +40 to damage per hit, but that sorta feels right. Giants and dragons become noticably more scary, to anything within their reach, as well they should be. It also fixes a lot of the "boss" fights that are too easy, which seems to be a pretty regular complaint that comes up, because a lot of bosses are actually BIG bad evil guys.
My players are currently too sold on the current system because if it's written that way they believe it that way. Fine. But don't come crying to me when you guys wipe the floor with a bunch of fire giants and are surprised the fight wasn't tougher.