Michael Silverbane
Adventurer
You can do these sorts of wounds in True20. I think there is an optional instant death rule where if you fail your death save by 20 or 25, you die.
So depending on the damage DC of the attack, and your Toughness save bonus, once you take a certain number of hits, any hit beyond that could either be something you shrug off, or could be your last depending on your Toughness roll.
This is (probably) similar to the damage mechanic in Mutants and Masterminds, where each damaging attack has a rank, usually near a predetermined 'power level'.
Whenever you are successfully attacked, you make a 'toughness save', which is capped at the predetermined 'power level'.
If you succeed on the save, you are unhurt.
If you fail the save, but by less than 5, you are injured. This applies a -1 penalty to future toughness saves.
If you fail the save by at least 5 but less than 10, you are injured and stunned. Stunned means you have to stand around for 1 round taking further butt-kickings.
If you fail by at least 10, but less than 15, you are injured, stunned, and disabled. Disabled means that if you do anything strenuous before you receive some sort of aid, you begin dying.
If you fail by at least 15, but less than 20, you are knocked unconscious and begin Dying.
If you fail by at least 20, you die.
The saves are weighted so that you are likely to fail them slightly, but it is possible to fail them badly. So, any given attack can either leave you completely unharmed (generally on a die roll result of 15+ on the toughness save) all the way to knocking you out of the action in one go (on a die roll result of 1-5 on the toughness save).