About three sessions into the first campaign I played with my current group, we chose to walk into a very bad spot against what turned out to be a cleric of Set (FR), his minions, and his very nasty staff (can't remember what it was exactly, though we were trying to stop it from leaving the city in his hands). In a few rounds, the five, third level adventurers were as follows:
Paladin, bodyguard: Deaf.
Duelist (rogue): Blind.
Wizard: Paralyzed.
Con-man (rogue): Cursed (Hefty Con damage).
Paladin's noble charge (rogue): Relatively fine.
Soon, we were all knocked unconscious and captured. Then we spent a month in the hold of a ship (these conditions still present the whole time). Thankfully, we were only sold into slavery afterwards.
Good times.