Only if you use encumberance....
If we start removing other rules, the comparables become more difficult.
If I don't use encumbrance, there's less reason for non-melee combatants to put points into STR. I could remove bonus skill points for INT and there's one less reason for characters to put points into INT, especially if they don't cast based on INT.
If we decide the game will revolve entirely around combat, with no social interaction (or, more common, all social interaction will be resolved by role playing, so the player's social skills are relevant and the character's are not), one less reason to sink points into CHA (or social skill ranks, for that matter).
At the extreme, we could provide no bonuses or penalties at all for characteristics - they're just flavor text and all Casters get the same number of spells with the same DC's, everyone with a club does the same damage, AC isn't changed by agility, all characters of the same level have the same save bonuses for favoured and non-favoured saves, etc.