Just a thought, but how much easier will tomb of horrors be now that we have access to at-will cantrips (mainly Mage hand so we don't have to stand next to the door to set it off?)
Probably! But the one thing that were I to run this for my players I'd have to remember and force myself to do... is to go against all my better instincts for how I like to run my games and never ask for Perception checks or coax players to tell me what they would like to do.
As I'm usually a "story-first" DM... I help my players by reminding them of things that have happened previously, or abilities they have but might have forgotten. Which would make Tomb of Horrors less deadly, if I'm constantly giving little bits of info off of ability checks that either I've prompted them to take or they just do for grand overviews of what they are experiencing.
Only if I play it completely blank and only speak when spoken to and give completely neutral information will I be able to run the game the way it was originally meant to be played and not like my typical 5E style game would go.