The unmentioned guides - Vampires Handbooks

[(Psi)SeveredHead]

That's because the 4e rules handle that.

PC who loses a healing surge with none left = take bloodied value in damage. Or, in other words, "Ouch!"

Not a vampire question, but in an upcoming encounter this is going to be really relevant for the PCs. Which rulebook holds this?

 

[MwaO]

Not a vampire question, but in an upcoming encounter this is going to be really relevant for the PCs. Which rulebook holds this?

It doesn't. Some effects specify what happens when a PC without any surges left lose one. A good rule of thumb is that you take 1/4 of your hp's worth of damage and if you're already unconscious, you in effect 'fail a death save'

I generally think it is a really bad idea to get anywhere close to that from a DM perspective. Make people die because they rolled a little poorly and used bad tactics, so they understand it was their decisions, not because they played a controller over a defender...

 

[AbdulAlhazred]

Not a vampire question, but in an upcoming encounter this is going to be really relevant for the PCs. Which rulebook holds this?

As others have said, there simply is no such rule in 4e. Its a common misconception because there are a number of situations where SPECIFIC rules state a loss of surge value if no surge is available, but without a general rule its a specific case-by-case thing, so if its not stated, there's no such loss.