I'm running a mega-dungeon in 4e, and we're having an amazing time. We've had moments when the players have to solve puzzles with terrain, getting completely lost through secret passages, stopped by dangerous fights they have to go around, multiple entrances and exits to explore. Down to their last healing surge and desperate to find a safe resting spot. All out of Daily powers. This 4e dungeon crawl is just as effective as any other edition of the game.
