Call of Cthulhu is still my favorite - the source material is pretty compelling and with a lot of awesome adventure material. Plus, questions like this give me a chance to flog one of the best RPG campaigns I've ever experienced, from both the player and Keeper side - The Masks of Nyarlathotep.
Though I do have to say that It Came from the Late, Late, Late Show did have its charms. Having a Scream skill was very valuable.