We've been using it primarily for a humor game we've been running, with no real plot other than whatever havoc our characters wreak.
The characters so far include Eugene, The Geneticist- a decidedly twisted 12 year old boy with a giant underground lab, various pets (including a winged octobunny and a squeeglyspooch flaying illithid who was once a dog), a machete, a watch that clones him upon death (though the clones are usually damaged somehow) and head (sans skull and various organs) which is permenantly grafted to his hand like some sort of squishy sock puppet.
DIR, The insane Taco craving robot.
Serial Number 1138 (formerly carl), Eugene's younger brother and first experiment. It is unknown what exists beneath his bandages (which completely wrap him up) but 1138 can control said bandages at will, as well as use them to open a can of magical whoop-a
Brain- A brain. In a jar. Attached to a robotic platform with a variety of uses (not the least of which being releasing a fluid into peoples' necks via hypodermic needle, causing their minds to turn to mush and to follow the brains psychic commands). He also has a legion of Samurai Squirrels.
Ned The Narcoleptic- A doctor with a tendency to fall asleep. While asleep, dreams he is a Jedi. Conveniently enough, he possesses two lightsabres.
Some Dude- some guy we found when we broke 1138 out of the loony bin. Seems to have the power to teleport, as well as travel through time space and beyond.
So far our antics have included preventing a hostage attempt, genetically altering the hostages after we saved them, scouring the city for tacos, pouring gene-altering fluid into the slurpee machine at the mall, creating several small armies, permenantly altering Eugene so that every time he speaks there's a 5% chance he'll break into song and be unnable to stop (with Winged Octobunnies playing the instruments) and combating a giant Michael Jackson clone, and taking out half of New Jersey in the process.
All in all a fun time.