Kae'Yoss said:
Monte's "WoD in Space" sounded good. Think Event Horizon. Think Alien.
It would be set in the future, but not too far. It probably wouldn't involve going to Mars to get some bagels.
To elaborate a bit, think of this:
Space is being conquered and explored, but it's still in the earliest of stages. Several planets and moons in our solar system have been made inhabitable on small scales (biodomes, confined stations, maybe even as much as limited terraforming on smaller bodies), but travel between earth and the outer colonies and outposts isn't something that is done in a matter of hours or even days - it takes months, and travelers are put into frozen slumber during the journey.
The colonies have limited ability to communicate with earth, but it's not instantaneous, and has limitations (you can't do it all the time, you have to wait for certain time windows, and the same goes for incoming transmissions).
And in the depths of space, the pioneers find that they find more than just resources, and that they brought more than just supplies....
Many humans, free at last from earth's field of influence, find that their latent magical abilities, muted by their homeworld awaken in the dephts of space, and mages are revealed.
Others find that they've been invaded by entities that seem to have lived in the endless void, with powers that resemble those we call vampires.
Others knew all along that they weren't normal humans, but overpopulated earth gave them little chance to run unfettered - werewolves find the seclusion from mother earth a welcome thing.
(though I could see vampires and werewolves trade places, or even both be from earth or both be from beyond)
Finally, some entities, away from the world's prying eyes, will hunt mankind if encountered in small, isolated groups. Survivors would tell us of demons if they let them.
It would make several scenarios possible:
Horror during transit: Stealing shamelessly from Alien, this involves travelers waking up way ahead of schedule, and finding something on board, stalking them (this could be a demon entering the ship or a vampire or werewolf). They might find that they have magical powers, or they might only have their wits at their disposal.
You could remake Event Horizon or Doom, with the new destination becoming a living hell.
You could also play supernaturals on one of the colonies, where they keep their secret from becoming known by the human colonists.