I think Goodman, Troll Lord, Frog God and LotFP have already proven there's a successful business for OSR. I think the real question is how well OSR companies can make good on WotC's early promises that 5E would be compatible with OSR materials. If the license, or whatever they're going to issue this fall, isn't as much of a mess as the 4E one, I can see OSR adventures and supplements being promoted to both audiences. (Obviously, Necromancer/Frog God is already taking their shot at this with their new Kickstarter.)
Honestly, I'm just looking forward to picking though both piles for my C&C campaign. Win-win for all involved.