Predictions:
1) Naruto will remain blond-haired and blue-eyed.
2) Sasuke will be black.
3) Sakura will be blond-haired, with optional blue eyes.
3b) Either that or Mexican.
4) Jiraya will be an old surfer dude.
5) Kakashi will be a contemplative ninja master who would never read porn in front of children.
6) Asumi will carry a pack of popsicles around.
7) Anko will wear a loose bodysuit (and the deconstruction continues; it was actually originally ring mail on a bodysuit, in the manga, according to a quote from the creator).
8) Kiba will be one of the few characters to not be a shade whiter.
9) Naruto's "demon side" will mostly consist of him getting growly and angry, but no real danger to anyone but some knocked-out bad guys.
10) Sexy Jutsu will not feature, in any form. ...This may be an improvement.
11) Iruka will loose any "ninja edge" he may have had, and never yell at children.
12) "Bloody Mist's" graduation exam will not feature, except possibly obliquely and very subtly in Haku's backstory.