You know what I want most?
A new D&D setting that blows my mind and gets me excited about running it.
It doesn't have to be "classic D&D" or "include all the monsters", just suitable for use with the bulk of D&D's rules, classes, races - if some or even many are excluded, that's fine!
I don't really care about any of the specifics, in fact, other than that it blows my mind and makes me really excited about running it - the thing about most of the settings I've been most impressed with and found most usable is that, actually, I hadn't thought of that beforehand.
The only thing tying together settings that made me go "Whoa, I want to run that!" is that virtually all of them were created by people with real vision, and knowledge of stuff like philosophy, world history outside of the Classical Era and the Middle Ages/Renaissance and mysticism, not just classic SF & Fantasy novels or the like, so I mean, that's something that's likely to be associated with anything that awesome.
I think it's really unlikely we'll see such a thing, because it would be inherently very risky to do right - requiring significant amounts of high-quality art, maps, full-colour and so on, and anything which has an opinion or an attitude or a point-of-view will piss some people off* (and my mind has never been blown by something that didn't), limiting the audience (really, though, I think not having that also limits the audience, because people don't get excited or interested as much).
Eberron wasn't far off, I note - a very high-quality setting and something of a point-of-view with it's "pulp" deal, but it ended up feeling a little designed-by-committee (even though it totally wasn't) and shorn of sharp corners for reasons I can't quite place. And that's my major fear here - that if we do get a new, exciting-seeming setting, it'll play it a little too safe, too conservative (not politically), too "normal", because WotC want to hit the broadest possible audience.
* = Absolutely goes for me too - some OSR stuff has a real, consistent, point-of-view that I don't vibe with, but I respect the hell out of it because it has an actual position, an actual style, an actual approach (LotFP, for example - I don't want to run or play that, despite owning some of it, but I like that it knows what it wants and how it wants to present it's world and so on).