Maybe "Otaku" can be offensive for somebody, but there is a Spanish magazine about manga with the name "Otaku Bunka", an also an English-languange magazine about manga+anime with the title "Otaku USA".
Japan realises the manga and the anime are very important for the "soft power". Maybe some Japanese people believe we can't understand them, but I guess a foreign living in Japan, speaking Japanese perfectly and even married with a Japanese can realise about certain things of the Japanese thanks because his point of view is different. Some days ago I found in youtube a channel of two Spanishs living in Japan, and telling things about Japanese society, with their virtues and flaws. Have you thought any time if Hasbro and Embracer Group (onwers of Asmodee and Fantasy Flight Games) mergered then "Legend of the Five Rings" could be added oficially to the D&D multiverse?
Hasbro is very interested in the Japanese market, at least as potential source of multimedia franchises. Transformers and Power Rangers are IPs with Japanese roots. When I was a little child I didn't mind at all Mazinger Z and other animes about mechas were from Japan.
Harems sound "exotic" to use a softer word, but in the real History there were the cause of continual civil wars for the succesion, because in the Muslims realms there wasn't the tradition of the firstborn to become the heir. The sultan Mehmed III the execution of his
19 brothers.
Somebody could to writte a fantasy story based in the Copt culture as a homage with the best intentions, but accidently to cause a misenundertanding and somebody would feel unconfortable.
In the same Northamerican citizens from Alaska, Miami, Texas, California and New York aren't identical also there are differences between the regions of Near and Middle Orient.
WotC could publish a new setting inspired in the ancient India but without the caste system.
Zakhara can be more "ideological neutral" if the main political factions are too linked with supernatural forces or sentient monsters, for example the genies, the dragons, the giants and "alien" creatures as the githyankis or the khaasta (planar raiders, reptilians)