D20 "Mutants & Masterminds" second edition
Yes, I and one of my role-players picked up Green Ronin's D20 "Mutants & Masterminds" 2nd Ed. book this past week. I play to run a one-shot of the revised superhero game this coming weekend.
I've played and run numerous comic book-based campaigns over the years, including the (D6) DC Heroes/Universe, Marvel Superheroes, Champions/Hero, GURPS Supers (2nd Ed., to be replaced by GURPS 4e "Powers"), and D20 "Silver Age Sentinels." Each has its own merits, but I'm pretty pleased by what I've seen so far in terms of M&M's streamlined rules, its descriptions of common superheroic concepts and styles, and its balancing of a point-based powers system with modified D20 rules.