Unless a game is tightly focused on survival, I'm generally not terribly interested in nitpicky, per-ounce encumbrances. On the other hand, I usually won't not consider weight/bulk at all in D&D, because, imo, having the risk of losing a pack, or less effective combat, or forced choices (like take the treasure versus take their comrades' body) makes for a better game. Genre depending, of course.
I prefer more abstract encumbrance systems, where items (or bundle of items) take up limited slots*; and/or are tracked probabilistically, eg, any item used might be the last. Abstract encumbrance still gives opportunities to impose interesting decisions on characters, without the fiddliness of tracking the weight and volume of every last doodad on their person.
* Slot systems are especially nice, imo, because they are easily translated into physical cards or tokens that make the tracking easier to adjust than numbers on a character sheet.