Our current 4e setting is very inclusive. However, I do want to do a less inclusive setting at some point.
A world of empires, where the PCs are from a mountainous region.
Dwarves, half-dwarves, raptorans, goliaths, humans, gnomes, halflings and some Genasi will be common. (oh and shardminds+warforged)
Half-elves (also known as el-taint) and some others, rare but possible.
Elves, also known as half-el, would be common in the enemy kingdom, which is ruled by Eladrin.