I have run entire campaigns like this. They are great fun, I do have a couple of suggestions.
1) Write your own stuff, published adventures in this vein tend to steam roll the players.
2) Cities are good, city states are better and Freeport rocks.
3) For each adventure make the ending a battle of some sort. For example. A noble's child turns up missing. Through much role-playing and investigation the PCs discover slavers have kidnapped the child. In the end the PCs battle the slavers. Without the climactic battle the game tends to get a little boring. It's also a good idea to throw in little fights from time to time. Maybe the local authorities are upset with the usurpers and goad them into a bar room brawl.
4) Make sure your players are into deep immersion, it is necessary for adventures of this type.