The good news is that, judging by the reaction here and other places online, it's pretty clear that there's plenty of interest in and demand for digital tools above and beyond PDFs (though that would definitely be a nice place to start).
That's good. WOTC is going to have to do *something*, even if "something" means nothing more than releasing some kind of licensing terms. The fact that they took a stab at DungeonScape's idea of integrating text and tools at the very least indicates that they were thinking of digital tools as part of their strategy, so it's unlikely they're just going to throw their hands up and say "well, we tried—all paper from here on out, folks".
If I had to guess, we'll probably see PDFs and Hero Lab for 5e, maybe very much in the Pathfinder model. There are plenty of good small-scale apps out there, but I can't think of anybody with a proven track record of working closely with a publisher and releasing content in a fashion that's readily monetizable like Lone Wolf. And they've expressed interest in doing it and frustration at the lack of licensing terms, so it's unlikely that their relationship with Paizo would preclude them from doing it.
I can understand why maybe WOTC wouldn't turn to them up front. Hero Lab is, well, a bit utilitarian. It's not pretty and sleek and the programming required to customize it is a bit of a barrier to entry. But it works, and they release content promptly.
So yeah, that's what I expect. Maybe we'll be pleasantly surprised and they'll just release fair licensing terms to everybody. Who knows?